Tony taldone

Scientific Advisor

Areas of Practice

Tony is an expert organic and medicinal chemist and group leader with over twelve years of experience in drug discovery and development and translational research with skills/expertise in all aspects of small-molecule drug discovery including preclinical and clinical development.  He has a strong research history focused on the development of novel anticancer agents, the generation of IP and in obtaining research funding.

 

Tony assists patent attorneys in drafting claims in patent applications, in preparing detailed chemical procedures for the synthesis and identification of chemical compounds and in preparing data tables of biological activity 

Education

  • Memorial Sloan Kettering Institute for Cancer Research, New York, NY, Postdoctoral Research Fellow/Associate, 2008-2013

  • St. John’s University, Ph.D., Medicinal Chemistry, 2008

  • St. John’s University, MS, Organic Chemistry, 2000 

  • St. John’s University, BS., Chemistry, 1999

Honor & Awards

  • Department of Defense, U.S. Army Postdoctoral Fellowship, 2010-2013 “Preclinical Development of Tumor-Specific Hsp70 Inhibitors in Breast Cancer” 

  • Komen for the Cure Postdoctoral Fellowship,  2009-2012 “Pre-clinical development of tumor specific Hsp70 inhibitors in breast cancer”

Professional Affiliations

  • American Chemical Society

  • American Association for Cancer Research

  • Peer reviewer for Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Current Organic Synthesis, MedChemComm, Expert Opinion on Drug Discovery, Recent Patents on Anti-Cancer Drug Discovery, Clinical Cancer Research, Tumor Biology, Letters in Organic Chemistry, Letters in Drug Design and Discovery, BioMed Research International, Journal of Sulfur Chemistry, Combinatorial Chemistry & High Throughput Screening, Journal of Heterocyclic Chemistry

Select Publications

  • Inda, M.C., Joshi, S., Wang, T., Bolaender, A., Gandu, S., Koren, J., Che, A. Y., Taldone, T., Yan, P., Sun, W.,  Uddin, M., Panchal, P., Riolo, M., Shah, S., Barlas, A., Xu, K., Chan,  L.  Y.  L., Gruzinova, A., Kishinevsky, S., Studer, L., Fossati, V., Noggle, S. A., White, J. R., de Stanchina, E., Sequeira, S., Anthoney, K. H., Steele, J. W.,  Manova-Todorova, K., Patil, S., Dunphy, M. P., Pillarsetty, N., Pereira, A. C., Erdjument-Bromage, H., Neubert, T. A., Rodina, A., Ginsberg, S. D., De Marco Garcia, N., Luo, W., Chiosis, G. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 11, 319 (2020).

  • Pillarsetty, N., Jhaveri, K., Taldone, T.#, Caldas-Lopes, E., Punzalan, B., Joshi, S., Bolaender, A., Uddin, M. M., Rodina, A., Yan, P., Ku, A., Ku, T., Shah, S. K., Lyashchenko, S., Burnazi, E.,  Wang, T., Lecomte, N., Janjigian,  Y., Younes, A., Batlevi, C. W., Guzman, M. L., Roboz, G. J., Koziorowski, J., Zanzonico, P., Alpaugh, M. L.,  Corben, A., Modi, S., Norton, L., Larson, S. M., Lewis, J. S., Chiosis, G., Gerecitano, J. F., Dunphy, M. P. S.  Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Cancer Cell. 11, 559-573.e7 (2019).

  • Taldone, T., Wang, T., Rodina, A., Pillarsetty, N., Digwal, C. S., Sharma, S., Yan, P., Joshi, S., Pagare, P. P.,  Bolaender, A., Roboz, G. J., Guzman, M. L., Chiosis, G. A chemical biology approach to the chaperome in cancer–HSP90 and beyond. Cold Spring Harb Perspect Biol. pii: a034116. (2019). doi: 10.1101/cshperspect.a034116.

  • Shrestha, L., Patel, H. J., Kang, Y., Sharma, S., Chiosis,  G.,  Taldone,  T.*  Copper  mediated coupling of 2-piperazine)-pyrimidine iodides with aryl thiols using Cu(I)thiophene-2-carboxylate. Tetrahedron Lett. 58, 4525 –4531 (2017).

  • Rodina, A., Wang, T., Yan, P., Gomes, E. D., Dunphy, M. P., Pillarsetty, N., Koren, J., Gerecitano, J. F., Taldone, T., Zong, H., Caldas-Lopes, E., Alpaugh, M., Corben, A., Riolo, M., Beattie, B., Pressl, C., Peter, R. I., Xu, C., Trondl, R., Patel, H. J., Shimizu, F., Bolaender, A., Yang, C. Panchal, P., Farooq, M. F., Kishinevsky, S., Modi, S., Lin, O., Chu, F., Patil, S., Erdjument-Bromage, H., Zanzonico, P., Hudis, C., Studer, L., Roboz, G. J., Cesarman, E., Cerchietti, L., Levine, R., Melnick, A., Larson, S. M., Lewis, J. S., Guzman, M. L., Chiosis, G. The epichaperome is an integrated chaperome network that facilitates tumour      survival. Nature. 538, 397-401 (2016).

  • Shrestha, L., Bolaender, A., Patel, H. J., Taldone, T.* Heat Shock Protein (HSP) Drug Discovery and Development: Targetin Heat Shock Proteins in Disease. Curr Top Med Chem. 16, 2753- 2764 (2016).

  • Taldone, T., Zatorska, D., Ochiana, S. O., Smith-Jones, P., Koziorowski, J., Dunphy, M.  P., Zanzonico, P., Bolaender, A., Lewis, J. S., Larson, S. M., Chiosis, G., Pillarsetty, N. V. Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71. J Labelled Comp Radiopharm.59, 129-132 (2016).

  • Patel, H. J., Patel, P. D., Ochiana, S. O., Yan, P., Sun, W., Patel, M., Shah, S. K., Tramentozzi, E., Brooks, J., Bolaender, A., Shrestha, L., Stephani, R. A., Finotti, P., Leifer, C., Li, Z., Gewirth, D. T., Taldone, T.*, Chiosis, G. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog, Grp94. J. Med. Chem. 58, 3922−3943 (2015).

  • Rodina, A., Taldone, T.#, Kang, Y., Patel, P. D., Koren, J. 3rd, Yan, P., DaGama Gomes, E. M., Yang, C., Patel, M. R., Shrestha, L., Ochiana, S. O., Santarossa, C., Maharaj, R., Gozman, A., Cox, M. B., Erdjument- Bromage, H., Hendrickson, R. C., Cerchietti, L., Melnick, A., Guzman, M.  L., Chiosis, G. Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer. ACS Chem. Biol. 9, 1698-1705 (2014).

  • Taldone, T., Patel, H. J., Bolaender, A., Patel, M. R., Chiosis, G. Protein  chaperones:  a composition of matter review (2008 - 2013). Expert Opin. Ther. Pat. 24, 501-518 (2014).

  • Taldone, T.*, Kang, Y., Patel, H. J., Patel, M. R., Patel, P. D., Rodina, A., Patel, Y., Gozman, A., Maharaj, R., Clement, C. C., Lu, A., Young, J. C., Chiosis, G. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3- (phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. J. Med. Chem. 57, 1208-1224 (2014).

  • Kang, Y., Taldone, T.*, Patel, H. J., Patel, P. D., Rodina, A., Gozman, A., Maharaj, R., Clement, C. C., Patel, M.R., Brodsky, J. L., Young, J. C., Chiosis. G. Heat shock protein 70 inhibitors. 1. 2,5'- thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. J. Med. Chem.  57, 1188-1207 (2014).

  • Taldone T.*, Patel, P. D., Patel, M., Patel, H. J., Evans, C. E., Rodina, A., Ochiana, S., Shah, S. K., Uddin, M., Gewirth, D., Chiosis, G. Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J. Med. Chem. 56, 6803-6818 (2013).

  • Taldone, T.*, Rodina, A., Dagama Gomes, E. M., Riolo, M., Patel, H. J., Alonso-Sabadell, R., Zatorska, D., Patel, M. R., Kishinevsky, S., Chiosis, G. Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Beilstein J. Org. Chem. 9, 544-556 (2013).

  • Taldone, T.*, Zatorska, D., Patel, H. J., Sun, W., Patel, M. R.,  Chiosis,  G.,  Preparation  of  a Diverse Purine-scaffold Library via One-step Palladium Catalyzed Cross-Coupling. Heterocycles. 87, 91-113 (2013).

  • Taldone, T.*, Patel, P. D., Patel, H. J., Chiosis, G. About the reaction of aryl fluorides with sodium sulfide: investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine. Tetrahedron Lett. 53, 2548-2551 (2012).

  • Taldone, T., Gomes-DaGama, E. M., Zong, H., Sen, S., Alpaugh, M. L., Zatorska, D., Alonso-Sabadell, R., Guzman, M. L., Chiosis, G. Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy. Bioorg. Med. Chem. Lett.21, 5347-5352 (2011).

  • Taldone, T., Zatorska, D., Patel, P. D., Zong, H., Rodina, A., Ahn, J. H., Moulick, K., Guzman, M. L., Chiosis, G. Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg. Med. Chem.19, 2603–2614 (2011).

  • Taldone, T., Gomes-DaGama, E. M., Zong, H., Sen, S., Alpaugh, M. L., Zatorska, D., Alonso-Sabadell, R., Guzman, M. L., Chiosis, G. Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy. Bioorg. Med. Chem. Lett. 21, 5347-5352 (2011).

  • Taldone, T., Zatorska, D., Patel, P. D., Zong, H., Rodina, A., Ahn, J. H., Moulick, K., Guzman, M. L., Chiosis, G. Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg. Med. Chem.19, 2603–2614 (2011)

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